导师姓名

王侃侃
研究方向 系统生物学;白血病发病机制
联系方式
通讯地址:上海市瑞金二路197号
邮政编码:200025
联系电话:64370045-611105
Email:kankanwang@hotmail.com
个人简介

   王侃侃,博士,研究员。2002年回国后加入上海交通大学医学院附属瑞金医院医学基因组学国家重点实验室,担任课题组组长,主要研究方向是应用系统生物学理念和方法研究白血病发生及治疗的分子机制,研究成果发表在Cancer Cell、Blood、PNAS、Oncogene、Cancer Research等国际知名刊物上。近年来,承担863、973和国家自然基金、上海市科委国际合作等多项国家级和省部级课题,并先后获得上海市科技启明星计划、启明星跟踪计划、教育部新世纪优秀人才计划、上海市曙光计划、明治乳业杰出奖等人才基金的资助。近年来的科研成果获得中华医学科技奖二等奖、上海市科技进步一等奖、教育部科技进步一等奖等。

代表性论著
1.Wang K, Wang P, Shi J, Zhu X, He M, Jia X, Yang X, Qiu F, Jin W, Qian M, Fang H, Mi J, Yang X, Xiao H, Mark Minden, Du Y, Chen Z, and Zhang J. PML/RAR Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia. Cancer Cell 2010, 17, 186-197 2.Yan J, Wang K, Dong L, Liu H, Chen W, Xi W, Ding Q, Kieffer N, Caen J, Chen S, Chen Z and Xi X. PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association. PNAS 2010, 107:3716-3721 3.Wang K, Fang H, Xiao D, Zhu X, He M, Pan X, Shi J, Zhang H, Jia X, Du Y and Zhang J. Converting Redox Signaling to Apoptotic Activities by Stress-Responsive Regulators HSF1 and NRF2 in Fenretinide Treated Cancer Cells. PLoS One 2009, 4, e7538 4.Fang H, Zhang J and Wang K. Connecting biological themes using a single human network of gene associations. IEEE Computer Society IJCBS 2009, 463-471 5.Luo R, Wei H, Ye L, Wang K, Chen F, Luo L, Liu L, Li Y, Crabbe MJ, Jin L, Li Y, and Zhong Y. Photosynthetic metabolism of C3 plants shows highly cooperative regulation under changing environments: a systems biological analysis. PNAS 2009, 106(3):847-852. 6.Fang H, Wang K, Zhang J. Transcriptome and proteome analyses of drug interactions with natural products. Current Drug Metabolism 2008, 9(10):1037-1047 7.Du Y, Wang K, Fang H, Li J, Xiao D, Zheng P, Chen Y, Pan X, Fan H, Zhao C, Zhang Q, Auffray C, Chen S, Chen Z and Zhang J. Coordination of Intrinsic, Extrinsic and Endoplasmic Reticulum- Mediated Apoptosis by Imatinib Mesylate Combined with Arsenic Trioxide in Chronic Myeloid Leukemia. Blood 2006, 107 (4) :1582-1590 8.Zheng P, Wang K, Zhang Q, Huang Q, Du Y, Zhang Q, Xiao D, Shen S, Imbeaud S, Eveno E, Zhao CJ, Chen YL, Fan HY, Waxman S, Auffray C, Jin G, Chen SJ, Chen Z and Zhang J. Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. PNAS 2005, 102:7653-7658



 

导师姓名

王侃侃
研究方向 白血病发生和治疗机制的研究
联系方式
通讯地址:上海市瑞金二路197号
邮政编码:200025
联系电话:64370045-611105
Email:kankanwang@hotmail.com
个人简介

   王侃侃,博士,研究员。2002年回国后加入上海交通大学医学院附属瑞金医院医学基因组学国家重点实验室,担任课题组组长,主要研究方向是应用系统生物学理念和方法研究白血病发生及治疗的分子机制,研究成果发表在Cancer Cell、Blood、PNAS、Oncogene、Cancer Research等国际知名刊物上。近年来,承担863、973和国家自然基金、上海市科委国际合作等多项国家级和省部级课题,并先后获得上海市科技启明星计划、启明星跟踪计划、教育部新世纪优秀人才计划、上海市曙光计划、明治乳业杰出奖等人才基金的资助。近年来的科研成果获得中华医学科技奖二等奖、上海市科技进步一等奖、教育部科技进步一等奖等。

代表性论著
1.Wang K, Wang P, Shi J, Zhu X, He M, Jia X, Yang X, Qiu F, Jin W, Qian M, Fang H, Mi J, Yang X, Xiao H, Mark Minden, Du Y, Chen Z, and Zhang J. PML/RAR Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia. Cancer Cell 2010, 17, 186-197 2.Yan J, Wang K, Dong L, Liu H, Chen W, Xi W, Ding Q, Kieffer N, Caen J, Chen S, Chen Z and Xi X. PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association. PNAS 2010, 107:3716-3721 3.Wang K, Fang H, Xiao D, Zhu X, He M, Pan X, Shi J, Zhang H, Jia X, Du Y and Zhang J. Converting Redox Signaling to Apoptotic Activities by Stress-Responsive Regulators HSF1 and NRF2 in Fenretinide Treated Cancer Cells. PLoS One 2009, 4, e7538 4.Fang H, Zhang J and Wang K. Connecting biological themes using a single human network of gene associations. IEEE Computer Society IJCBS 2009, 463-471 5.Luo R, Wei H, Ye L, Wang K, Chen F, Luo L, Liu L, Li Y, Crabbe MJ, Jin L, Li Y, and Zhong Y. Photosynthetic metabolism of C3 plants shows highly cooperative regulation under changing environments: a systems biological analysis. PNAS 2009, 106(3):847-852. 6.Fang H, Wang K, Zhang J. Transcriptome and proteome analyses of drug interactions with natural products. Current Drug Metabolism 2008, 9(10):1037-1047 7.Du Y, Wang K, Fang H, Li J, Xiao D, Zheng P, Chen Y, Pan X, Fan H, Zhao C, Zhang Q, Auffray C, Chen S, Chen Z and Zhang J. Coordination of Intrinsic, Extrinsic and Endoplasmic Reticulum- Mediated Apoptosis by Imatinib Mesylate Combined with Arsenic Trioxide in Chronic Myeloid Leukemia. Blood 2006, 107 (4) :1582-1590 8.Zheng P, Wang K, Zhang Q, Huang Q, Du Y, Zhang Q, Xiao D, Shen S, Imbeaud S, Eveno E, Zhao CJ, Chen YL, Fan HY, Waxman S, Auffray C, Jin G, Chen SJ, Chen Z and Zhang J. Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. PNAS 2005, 102:7653-7658